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NFL Match Results: San Francisco
| Week | Result | Margin | Scores | Opponent | Venue |
| 2025 Week 18 | LOST | 10 | 3 - 13 | Seattle | Home |
| 2025 Week 17 | WON | 4 | 42 - 38 | Chicago | Home |
| 2025 Week 16 | WON | 21 | 27 - 48 | Indianapolis | Away |
| 2025 Week 15 | WON | 13 | 37 - 24 | Tennessee | Home |
| 2025 Week 13 | WON | 18 | 8 - 26 | Cleveland | Away |
| 2025 Week 12 | WON | 11 | 20 - 9 | Carolina | Home |
| 2025 Week 11 | WON | 19 | 22 - 41 | Arizona | Away |
| 2025 Week 10 | LOST | 16 | 26 - 42 | LA Rams | Home |
| 2025 Week 9 | WON | 10 | 24 - 34 | NY Giants | Away |
| 2025 Week 8 | LOST | 11 | 26 - 15 | Houston | Away |
| 2025 Week 7 | WON | 10 | 20 - 10 | Atlanta | Home |
| 2025 Week 6 | LOST | 11 | 30 - 19 | Tampa Bay | Away |
| 2025 Week 5 | WON | 3 | 23 - 26 | LA Rams | Away |
| 2025 Week 4 | LOST | 5 | 21 - 26 | Jacksonville | Home |
| 2025 Week 3 | WON | 1 | 16 - 15 | Arizona | Home |
| 2025 Week 2 | WON | 5 | 21 - 26 | New Orleans | Away |
| 2025 Week 1 | WON | 4 | 13 - 17 | Seattle | Away |
| 2024 Week 18 | LOST | 23 | 47 - 24 | Arizona | Away |
| 2024 Week 17 | LOST | 6 | 34 - 40 | Detroit | Home |
| 2024 Week 16 | LOST | 12 | 29 - 17 | Miami | Away |
